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Medchemexpress LLC Hki-357 | 848133-17-5 | MFCD26792555 | 98.1% | 574.05 g·mol⁻¹ | C31H29ClFN5O3 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1034431MG

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HKI-357 is a small-molecule, irreversible dual inhibitor of EGFR and ERBB2 tyrosine kinases intended for research use. It shows low-nanomolar potency and suppresses EGFR autophosphorylation and downstream signaling, making it useful for cellular and biochemical studies of EGFR/HER2 pathways.

  • Irreversible dual inhibition of EGFR and ERBB2.
  • Reported potency: EGFR IC50 ≈ 34 nM; ERBB2 IC50 ≈ 33 nM.
  • Suppresses EGFR autophosphorylation at Y1068 and downstream AKT and MAPK phosphorylation.
  • Supplied as a solid research compound with recommended cold storage for long-term stability.
  • Molecular formula C31H29ClFN5O3; molecular weight 574.05 g·mol⁻¹.

Catalog No. 50-002-46336


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