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Medchemexpress LLC Hki-357 | 848133-17-5 | MFCD26792555 | 99.2% | 574.05 g·mol⁻¹ | C31H29ClFN5O3 | 25 MG
Supplier: Medchemexpress LLC HY10344325MG
HKI-357 is a small-molecule, irreversible dual inhibitor of EGFR and ERBB2 used for research applications. It shows low-nanomolar potency (IC50 EGFR 34 nM; ERBB2 33 nM) and suppresses EGFR autophosphorylation at Y1068 and downstream AKT and MAPK signaling. Intended for research use only.
- Irreversible dual inhibition of EGFR and ERBB2 at low-nanomolar potency.
- Suppresses EGFR autophosphorylation (Y1068) and downstream AKT and MAPK signaling.
- Reported IC50s of 34 nM (EGFR) and 33 nM (ERBB2) for biochemical potency.
- High purity suitable for in vitro research and biochemical assays.
- Well-defined molecular formula and molecular weight facilitate analysis.
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