ABclonal Technology HLA-DPB1 Rabbit mAb

Supplier:  ABclonal Technology A2579420UL

HLA-DPB belongs to the HLA class II beta chain paralogues This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB) both anchored in the membrane It plays a central role in the immune system by presenting peptides derived from extracellular proteins Class II molecules are expressed in antigen presenting cells (APC B lymphocytes dendritic cells macrophages) The beta chain is approximately 26-28 kDa and its gene contains 6 exons Exon one encodes the leader peptide exons 2 and 3 encode the two extracellular domains exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities resulting in up to 4 different molecules

Catalog No. 50-000-13234