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Medchemexpress LLC Homogentisic acid | 451-13-8 | 99.5% | 168.15 | 1 ML
Supplier: Medchemexpress LLC HY11328310MM/1ML
Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Its accumulation leads to the downregulation of tight junction proteins (such as claudin-5, occludin, and ZO-1) and impairs the integrity of the blood-brain barrier. It is a tool molecule for investigating mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer.
- Orally active and blood-brain barrier-permeable
- Important tool molecule for investigating mechanisms of diseases
- At specific concentrations, it exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes and counteracts genotoxicity induced by Irinotecan
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