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Medchemexpress LLC HP590 | 2971855-37-3 | C29H24F6N4O3 | 5 MG
Supplier: Medchemexpress LLC HY1514805MG
HP590 is a novel, potent, and orally active STAT3 inhibitor. It demonstrates anti-proliferative activity in gastric cancer cells and induces apoptosis, inhibiting STAT3 luciferase activity with an IC50 of 27.8 nM and ATP inhibition with an IC50 of 24.7 nM.
- Exhibits anti-proliferative activities against gastric cancer cells such as MKN45, AGS, and MGC803.
- Induces apoptosis in gastric cancer cells.
- Inhibits STAT3 Tyr705 and Ser727 phosphorylation in gastric cancer cells.
- Blocks the expression of STAT3 downstream genes like c-Myc and cyclin D1.
- Reduces IL-6-mediated STAT3 nuclear translocation.
- Inhibits gastric cancer growth in BALB/c-nude mice xenograft models.
- Shows better tolerance in xenograft models, with no weight loss or apparent damage to major organs.
- Inhibits the expression of Ki67, a proliferation marker.
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