Apexbio Technology LLC HPOB 1429651-50-2 10mg

Supplier:  Apexbio Technology LLC B489010

HPOB (CAS 1429651-50-2) is a selective inhibitor of histone deacetylase 6 (HDAC6) exhibiting an IC50 of 56 nM and over 30-fold reduced potency against other HDAC isoforms HDAC6 is a zinc-dependent deacetylase involved in the regulation of microtubule dynamics and protein quality control through its dual catalytic domains and a C-terminal ubiquitin-binding domain In cell-based assays HPOB induces -tubulin acetylation without affecting histone acetylation and inhibits the proliferation of normal HFS and modified LNCaP cells while preserving cell viability Additionally HPOB enhances the cytotoxic effects of etoposide doxorubicin and SAHA in transformed cells by promoting apoptosis and activating DNA damage response pathways In vivo HPOB is well tolerated in mice bearing human prostate cancer xenografts and augments the antitumor activity of SAHA

Catalog No. 50-000-88685