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Medchemexpress LLC HS-276 | 2767422-72-8 | 98.9% | 419.52 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY147141

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HS-276 is an orally active, potent, and highly selective TAK1 inhibitor with a Ki of 2.5 nM. It significantly inhibits TAK1 and other kinases including CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1. This compound is useful for research related to rheumatoid arthritis (RA) by reducing the expression of TNF, IL-6, and IL-1β in a dose-dependent manner.

  • Potent and highly selective TAK1 inhibitor
  • Reduces inflammation, pannus formation, cartilage damage, bone resorption, and periosteal bone formation in inflammatory arthritis models
  • Exhibits excellent oral bioavailability in mice

Catalog No. 50-003-63590


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