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Medchemexpress LLC HS-276 | 2767422-72-8 | 98.9% | 419.52 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1471415MG

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HS-276 is an orally active, potent, and highly selective TAK1 inhibitor with a Ki of 2.5 nM. It significantly inhibits multiple kinases including TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1. It reduces the expression of TNF, IL-6, and IL-1β in a dose-dependent manner and shows excellent bioavailability in mice, making it suitable for rheumatoid arthritis (RA) research.

  • Orally active and highly selective TAK1 inhibitor
  • Significant inhibition of multiple kinases
  • Reduces expression of inflammatory cytokines
  • Demonstrates excellent bioavailability in vivo
  • Suitable for rheumatoid arthritis research

Catalog No. 50-003-63822


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