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Medchemexpress LLC HS-276 | 2767422-72-8 | 98.9% | 419.52 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY14714150MG

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HS-276 is an orally active, potent, and highly selective TAK1 inhibitor. It significantly inhibits multiple kinases including TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1. This compound can be utilized for rheumatoid arthritis (RA) research, reducing the expression of TNF, IL-6, and IL-1β in a dose-dependent manner. In vivo studies have shown its effectiveness in reducing inflammation and related histological manifestations in a CIA mouse model of inflammatory arthritis.

  • Potent and selective TAK1 inhibitor with a Ki of 2.5 nM
  • Inhibits multiple kinases including CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1
  • Reduces expression of TNF, IL-6, and IL-1β in vitro
  • Effective in a CIA mouse model of inflammatory arthritis, reducing inflammation and bone damage
  • Exhibits excellent bioavailability in CD-1 mice

Catalog No. 50-003-60816


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