Apexbio Technology LLC HSP990 (NVP-HSP990) 934343-74-5 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B47975.1

HSP990 (NVP-HSP990 CAS 934343-74-5) is a small molecule inhibitor targeting heat shock protein 90 (HSP90) specifically binding the N-terminal ATP-binding domain of Hsp90 Hsp90 and Grp94 with IC50 values of 0 6 0 8 and 8 5 nM respectively HSP990 inhibits TRAP1 ATPase activity (IC50 320 nM) and destabilizes the Hsp90-p23 complex in GTL-16 cells in a concentration- and time-dependent manner The compound reduces c-Met levels induces Hsp70 (EC50 37 nM and 20 nM respectively) and inhibits phosphorylation of ERK and AKT (EC50 11 and 6 nM) leading to suppression of cell proliferation in multiple tumor cell lines (GI50 4 40 nM) In vivo HSP990 has demonstrated antitumor activity in murine gastric cancer models

Catalog No. 50-000-90429