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Sino Biological Recombinant Human CCR5 Protein (Flag & His-Strep Tag), Detergent
Supplier: Sino Biological 13022H82HDD100
A DNA sequence encoding the Human CCR5-Detergent (P51681)(Met1-Arg319) was expressed, with a Flag tag at the N-terminus, a polyhistidine tag and a strep tag at the C-terminus. Within the expressed regions, there are several proprietary thermostabilizing mutations.This protein was prepared using our detergent platform. The transmembrane proteins' hydrophobic regions pose a challenge in maintaining their native conformation post-extraction from cellular membranes in standard buffers. To address this, our detergent technology platform utilizes a traditional yet proven membrane protein extraction method, incorporating detergents to stabilize the proteins. This method efficiently produces highly purified membrane protein products, suitable for use in early drug screening and research applications.
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