Discovery Life Sciences HUMAN CYP3A+P450 REDUCTASE

Supplier:  Discovery Life Sciences 456202

Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs. CYP3A4 is on average the most abundant P450 in human liver. It is considered the most important P450 for drug metabolism, accounting for the metabolism of 50% or more of prescribed medications. CYP3A4 is also a major isoform in the intestine and can contribute significantly to oral first-pass metabolism of drugs. CYP3A4 metabolizes cortisol, nifedipine, cyclosporin, testosterone, estrogen, (R)-warfarin, gestodene, ketoconazole, miconazole, dapsone, FK-506, quinidine, lovastatin, erythromycin, and numerous other drugs. It is involved in many clinically important drug-drug interactions. CYP3A4 activates aflatoxin B1-related Carcinogens and senecionine. CYP3A4 protein levels can be induced several fold in the liver by ligands of CAR and PXR (e.g., phenobarbital, rifampin, and phenytoin). Contains Human Oxidoreductase and cytochrome b5

Catalog No. NC1088410