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Medchemexpress LLC HY-078020 | 2756222-90-7 | 98.9% | 515.09 | 5 MG
Supplier: Medchemexpress LLC HY1622315MG
HY-078020 (compound III-4) is a selective, orally active antagonist for the histamine H1 receptor with an IC50 of 24.12 nM. It exhibits an anti-inflammatory effect in allergic diseases.
- Selective, orally active histamine H1 receptor antagonist.
- Exhibits an anti-inflammatory effect in allergic diseases.
- Potent inhibitory activity towards H1R (IC50 of 24.12 nM).
- Weak inhibition against M3R and hERG.
- Moderate permeability and good liver microsome stability.
- Long half-life in human, beagles, and mice.
- Inhibits cytochrome P450 (CYP) isozyme CYP3A4.
- Inhibits histamine-induced skin vasodilation and capillary permeability in mice.
- Exhibits weak anticholinergic activity in mice.
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