Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Hydrastine | 118-08-1 | 99.6% | 1 ML
Supplier: Medchemexpress LLC HYB092710MM/1ML
Hydrastine is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis with an IC50 of 20.7 μM in PC12 cells. It also acts as an inhibitor of the organic cation transporter OCT1 with an IC50 of 6.6 μM. Hydrastine may induce neuronal toxicity through mitochondrial dysfunction and can exacerbate cell apoptosis when combined with L-DOPA, making it suitable for studying Parkinson's disease-related dopaminergic neuronal damage.
- Selective competitive inhibitor of tyrosine hydroxylase (TH)
- Inhibits dopamine biosynthesis
- Inhibitor of the organic cation transporter OCT1
- Induces neuronal toxicity via mitochondrial dysfunction
- Exacerbates cell apoptosis when combined with L-DOPA
- Suitable for studying Parkinson's disease-related dopaminergic neuronal damage
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?