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Medchemexpress LLC Iadademstat (dihydrochloride) | 1431303-72-8 | 100.0% | 100 MG
Supplier: Medchemexpress LLC HY12782T100MG
Iadademstat dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor. It inactivates KDM1A by irreversibly binding to the flavin adenine nucleotide (FAD) cofactor. This compound shows high selectivity for KDM1A over MAO enzymes and KDM1B, and potent subnanomolar cellular activity against mixed lineage leukemia (MLL)-translocated acute myeloid leukemia (AML) cell lines. It reduces AML tumor growth in animal xenografts and prolongs survival in T-ALL models.
- Selective irreversible KDM1A/LSD1 inhibitor
- Inactivates KDM1A by binding to FAD cofactor
- High selectivity for KDM1A over MAO enzymes and KDM1B
- Potent subnanomolar cellular activity against MLL-translocated AML cell lines
- Reduces AML tumor growth in animal xenografts
- Prolongs survival in disseminated T-ALL models
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