Medchemexpress LLC Ibezapolstat | 1275582-97-2 | 98.0% | 50 MG

Supplier:  Medchemexpress LLC HY12835750MG

Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor developed for research into *C. difficile* infection (CDI). It binds to and inhibits DNA pol IIIC from aerobic and low G+C Gram-positive bacteria, demonstrating antibacterial activities against a broad spectrum of *C. difficile* pathogens in vitro. In vivo studies suggest it is poorly absorbed and nontoxic in the hamster CDAD model, indicating its potential for achieving high local concentrations at the infection site.

• First-in-class, orally active DNA polymerase IIIC inhibitor
• Inhibits DNA pol IIIC from aerobic and low G+C Gram-positive bacteria
• Exhibits antibacterial activities against a broad spectrum of *C. difficile* pathogens
• Poorly absorbed and apparently nontoxic in animal models
• Potential for high local concentration at the site of infection

Catalog No. 50-003-38165