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Medchemexpress LLC Ibezapolstat (ACX-362E) | 1275582-97-2 | 98.0% | 100 MG
Supplier: Medchemexpress LLC HY128357100MG
Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC inhibitor developed for the research of *C. difficile* infection (CDI). It demonstrates antibacterial activity against a broad spectrum of *C. difficile* pathogens by inhibiting DNA pol IIIC from aerobic and low G+C Gram-positive bacteria. This compound is poorly absorbed, suggesting potential for high local concentrations at the site of infection in the colon, and has shown strong anti-*C. difficile* properties in vivo.
- First-in-class, orally active DNA polymerase IIIC inhibitor
- Developed for *C. difficile* infection (CDI) research
- Exhibits antibacterial activity against *C. difficile* pathogens
- Inhibits DNA pol IIIC from aerobic and low G+C Gram-positive bacteria
- Poorly absorbed in vivo, promoting local concentration at infection site
- Demonstrates strong anti-*C. difficile* properties in animal models
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