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Apexbio Technology LLC IC261 186611-52-9 5mg
Supplier: Apexbio Technology LLC B61085
IC261 (CAS 186611-52-9) is a small molecule inhibitor of casein kinase 1 delta (CK1 ) and epsilon (CK1 ) exhibiting an IC50 of 16 M These kinases are involved in the regulation of DNA repair and chromosome segregation In vitro IC261 interrupts mitotic progression at low micromolar concentrations causing transient mitotic arrest cells with functional p53 are blocked in G1 post-mitosis while p53-deficient cells display post-mitotic DNA re-replication increased micronuclei and apoptosis IC261 also promotes centrosome amplification and multipolar mitoses In animal models intrathecal administration reduces mechanical allodynia and thermal hyperalgesia dose-dependently IC261 remains under preclinical investigation as a research tool in cell cycle DNA damage response and pain models
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