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Medchemexpress LLC ICA 110381 | 325457-99-6 | 99.8% | 267.11 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY10858750MG

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ICA 110381 is an orally active Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator with anticonvulsive properties. It acts as a KCNQ2/Q3 activator with an EC50 of 0.38 μM and also as a KCNQ1 antagonist with an IC50 of 15 μM.

  • Can be administered orally.
  • Targets specific potassium channels.
  • Helps in preventing or reducing the severity of seizures.
  • Induces rubidium efflux in CHO cells expressing KCNQ2 or KCNQ3 (EC50 = 0.38 μM).
  • Inhibits rubidium efflux from CHO cells expressing KCNQ1 (EC50 = 15 μM).
  • Damps neuronal excitability in CA1 pyramidal cells by increasing M-currents (IM), reducing input resistance, and shifting the resting membrane potential hyperpolarizing direction.
  • Elevates threshold for afterdischarges, reducing seizure severity and duration in amygdala-kindled rats.

Catalog No. 50-003-46220


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