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Medchemexpress LLC ICCB-19 hydrochloride | 1803605-68-6 | 99.3% | 291.84 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY138779

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ICCB-19 hydrochloride is an indirect inhibitor of RIPK1 kinase activity and a TRADD (TNFRSF1A associated via death domain) inhibitor. It functions by binding with the N-terminal domain of TRADD (TRADD-N), which disrupts its binding to both TRADD-C and TRAF2. This compound effectively induces autophagy and the degradation of long-lived proteins.

  • Inhibits Bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM.
  • Promotes autophagy via K63-linked ubiquitination of beclin 1.
  • Reduces inflammatory responses in Tradd-/- mice.
  • Reduces expression of TNF-induced inflammatory target gene products and cytokines.

Catalog No. 50-003-48138


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