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Apexbio Technology LLC Icotinib 610798-31-7 5mg
Supplier: Apexbio Technology LLC B14965
Icotinib (CAS 610798-31-7) is a small molecule inhibitor targeting the epidermal growth factor receptor (EGFR) tyrosine kinase exhibiting an in vitro IC50 of 5 nM EGFR a transmembrane tyrosine kinase receptor plays a central role in cell proliferation motility and apoptosis and is overexpressed in various cancers including non-small cell lung cancer (NSCLC) breast ovarian and head and neck cancers Icotinib inhibits EGF-induced EGFR phosphorylation and downstream tyrosine phosphorylation of intracellular proteins in human carcinoma A431 cells in a dose-dependent manner In animal models icotinib suppresses tumor growth without significant toxicity It is of interest for preclinical and clinical research on EGFR-driven malignancies
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