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Medchemexpress LLC iE-DAP dihydrochloride | 99.7% | 392.23 | 1 MG
Supplier: Medchemexpress LLC HYP5523A1MG
iE-DAP dihydrochloride is a Nod1 agonist. It activates the NOD1 receptor, triggering NF-κB and MLCK signaling pathways, which lead to cellular inflammatory responses and tight junction disruption. It downregulates ZO-1 and Occludin genes. In human trophoblast cell cultures, it increases secretion of cytokines like IL-6, GRO-α, MCP-1, IL-8, and MIP-1β. In pregnant mice, iE-DAP dihydrochloride induces preterm birth, reduces fetal body weight, and causes fetal inflammation, making it applicable for studies related to mastitis and preterm birth.
- Nod1 agonist.
- Activates NF-κB and MLCK signaling pathways.
- Downregulates ZO-1 and Occludin genes.
- Increases secretion of inflammatory cytokines.
- Induces preterm birth in pregnant mice.
- Relevant for mastitis and preterm birth studies.
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