Apexbio Technology LLC (+)-Igmesine hydrochloride 130152-35-1 10mg

Supplier:  Apexbio Technology LLC B529410

( )-Igmesine hydrochloride (CAS 130152-35-1) is a selective sigma-1 ( 1) receptor ligand with an IC50 of 19 1 nM Sigma-1 receptor modulators are known to influence central neurotransmitter systems including noradrenergic glutamatergic and dopaminergic pathways In vitro studies indicate that treatment with ( )-Igmesine leads to a notable reduction in -adrenergic receptor density and tyrosine hydroxylase activity without affecting 1 5-HT1A or GABAB receptor levels The compound does not inhibit monoamine oxidase A or B activity In vivo it exhibits limited effects on norepinephrine uptake and does not alter serotonin or dopamine synthesis ( )-Igmesine also interferes with the NMDA receptor/NOS/cGMP pathway It is primarily utilized in research investigating sigma-1 receptor functions and potential antidepressant mechanisms Clinical studies have not yet been conducted

Catalog No. 50-000-88900