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Medchemexpress LLC IHMT-MST1-58 | 2414484-25-4 | C21H22N6O3S | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1512575MG

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IHMT-MST1-58 is a potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor with an IC50 value of 23 nM. It can be utilized for research related to Type 1/2 diabetes.

  • Potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor.
  • IC50 value of 23 nM against MST1.
  • Used for research of Type 1/2 diabetes.
  • Strong inhibitory activity against MST1 (IC50 = 23 nM) and weak activity against MST2 (IC50 = 652 nM).
  • Inhibits phosphorylation of MST1 in vitro.
  • Protective effect on β cells from inflammatory cytokines.
  • Combined with metformin, it decreased fasting blood glucose and hemoglobin A1c levels in STZ-induced T1D/T2D mouse models.

Catalog No. 50-003-75936


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