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AdipoGen IHR-1 (1 mg)
Supplier: AdipoGen AGCR13526M001
Chemical. CAS: 548779-60-8. Formula: C20H12Cl4N2O2. MW: 454.1. Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
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