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Medchemexpress LLC IKK 16 | 873225-46-8 | 99.9% | 483.63 | 1 ML
Supplier: Medchemexpress LLC HY1368710MM/1ML
IKK 16 is an orally active inhibitor targeting IKK, PKD, and ABCB1 pathways. It demonstrates potent inhibitory activity against IKK2, IKK complex, IKK1, and LRRK2, as well as PKD1, PKD2, and PKD3. This compound offers protective effects against LPS-induced organ dysfunction, supports renal function recovery, and helps reduce fibrosis in acute kidney injury. It also attenuates cardiac dysfunction in models of polymicrobial sepsis with type 2 diabetes mellitus by modulating the NF-κB pathway.
- Orally active IKK inhibitor
- Functions as a pan-PKD inhibitor
- Inhibits ABCB1, interfering with substrate binding
- Protects against LPS-induced multiple organ dysfunction
- Restores renal function and alleviates fibrosis in acute kidney injury
- Attenuates cardiac dysfunction in polymicrobial sepsis models
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