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Medchemexpress LLC Ilginatinib hydrochloride (NS-018 hydrochloride) | 1239358-85-0 | 98.9% | 425.89 | 1 ML
Supplier: Medchemexpress LLC HY19631B10MM/1ML
Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable JAK2 inhibitor. It demonstrates significant selectivity for JAK2 over other JAK family members and inhibits Src-family kinases. This compound exhibits potent inhibitory activity against cell lines with specific JAK2 mutations, showing minimal cytotoxicity to other hematopoietic cell lines.
- Highly active and orally bioavailable JAK2 inhibitor
- Shows selectivity for JAK2 over JAK1, JAK3, and Tyk2
- Inhibits Src-family kinases (SRC and FYN)
- Weakly inhibits ABL and FLT3
- Potent inhibitory activity against cell lines with JAK2V617F or MPLW515L mutations
- Minimal cytotoxicity against hematopoietic cell lines lacking constitutively activated JAK2
- For research use only
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