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Apexbio Technology LLC Imatinib hydrochloride 862366-25-4 100mg
Supplier: Apexbio Technology LLC A3487100
Imatinib hydrochloride is a small-molecule inhibitor targeting receptor tyrosine kinases notably v-Abl c-Kit and PDGFR It is designed to competitively inhibit the ATP-binding site of these kinases thereby blocking downstream phosphorylation events involved in cellular proliferation and differentiation Imatinib hydrochloride exerts its biological activity primarily through inhibition of kinase activity In cellular assays Imatinib demonstrates kinase inhibition with reported IC50 values of approximately 0 6 M for v-Abl and near 0 1 M for c-Kit and PDGFR Based on these pharmacological properties Imatinib hydrochloride holds research potential in oncology particularly for studies on chronic myelogenous leukemia gastrointestinal stromal tumors dermatofibrosarcoma protuberans and systemic mastocytosis
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