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Medchemexpress LLC Indole-3-carbinol | 700-06-1 | 99.2% | 147.18 | 10 G
Supplier: Medchemexpress LLC HYN017010G
Indole-3-carbinol (I3C) is an endogenous metabolite that inhibits NF-κB activity, acts as an Aryl hydrocarbon receptor (AhR) agonist, and is an inhibitor of WWP1. For research use only.
- Inhibits NF-κB activity.
- Aryl hydrocarbon receptor (AhR) agonist.
- Inhibitor of WWP1.
- Inhibits THP-1 cell proliferation with minimal toxicity.
- Overexpresses AhR target genes (CYP1A1, IL1β).
- Antiproliferative effects linked to programmed cell death; downregulates BCL2, upregulates FasR in THP-1 cells.
- Induces G1 cell cycle arrest; overexpresses G1-acting cell cycle genes (P21, P27, P53), downregulates CDK2.
- Suppresses NF-κB activity and stimulates p53 pathway in pre-B acute lymphoblastic leukemia cells.
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