STEMCELL Technologies R428, Size: 1 mg

Supplier:  STEMCELL Technologies 1000566

R428 is a potent and selective inhibitor of Axl (IC50 = 14 nM) with antiproliferative activity (Holland et al.). Axl is a receptor tyrosine kinase that is involved in cell survival, proliferation, adhesion, and migration (Chen et al.). R428 exhibits over 100-fold selectivity for Axl over insulin receptor, epidermal growth factor receptor, human epidermal growth factor receptor 2, and platelet-derived growth factor receptor β (Holland et al.). DIFFERENTIATION· Inhibits preadipocyte differentiation into mature adipocytes (Lijnen et al.).· Induces beta cell maturation from human induced pluripotent stem cells (Kushner et al.; Yabe et al.).CANCER RESEARCH· Inhibits Axl expression and breast cancer cell metastasis (Holland et al.).· Blocks lysosomal acidification and induces apoptosis in cancer cells (Chen et al.).

Catalog No. 50-206-9374