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Apexbio Technology LLC IPA-3 42521-82-4 50mg
Supplier: Apexbio Technology LLC B216950
IPA-3 (CAS 42521-82-4) is a selective small molecule inhibitor targeting the autoregulatory domain of p21-activated kinase (Pak) It inhibits Pak1 activity in an ATP-independent manner exhibiting an IC50 of approximately 2 5 M in kinase assays In vitro studies indicate that IPA-3 effectively reduces Pak1 autophosphorylation triggered by CDC42 or sphingosine stimulation Additionally IPA-3 (10 M) inhibits the activity of Pak isoforms Pak2 and Pak3 and at 30 M suppresses both basal and PDGF-induced Pak activation in mouse embryonic fibroblast cells IPA-3 serves as a valuable tool in investigating Pak signaling pathways in cellular biology and disease models
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