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Medchemexpress LLC Ipatasertib | 1001264-89-6 | C24H32ClN5O2 | 1 ML
Supplier: Medchemexpress LLC HY1518610MM/1ML
Ipatasertib (GDC-0068) is an orally active, highly selective, and ATP-competitive pan-Akt inhibitor with IC50 values of 5, 18, and 8 nM for Akt1, Akt2, and Akt3, respectively. It synchronously activates FoxO3a and NF-κB by inhibiting Akt, leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.
- Orally active
- Highly selective and ATP-competitive pan-Akt inhibitor
- Induces apoptosis in cancer cells
- Inhibits tumor growth in xenograft mouse models
- Purity: 99.79%
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