Medchemexpress LLC Ipatasertib | 1001264-89-6 | C24H32ClN5O2 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY15186

Ipatasertib (GDC-0068) is an orally active, highly selective, and ATP-competitive pan-Akt inhibitor with IC50 values of 5, 18, and 8 nM for Akt1, Akt2, and Akt3, respectively. It synchronously activates FoxO3a and NF-κB through Akt inhibition, leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.

• Purity 99.79%
• Targets Akt1 (5 nM), Akt2 (18 nM), Akt3 (8 nM), and PKA (3100 nM)
• Demonstrates antiproliferative activity against various human cell lines
• Suppresses colon cancer cell proliferation by activating PUMA in vitro
• Exhibits PUMA-dependent antitumor activity in xenograft mouse models

Catalog No. 50-003-75994