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Medchemexpress LLC Ipragliflozin (L-Proline) | 951382-34-6 | 99.9% | 519.58 | 50 MG
Supplier: Medchemexpress LLC HY14894A50MG
Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM. It shows little to no potency for SGLT1/3/4/5/6.
- Potently and selectively inhibits human, rat, and mouse SGLT2 at nanomolar ranges.
- Exhibits stability against intestinal glucosidases.
- Demonstrates good pharmacokinetic properties after oral dosing.
- Dose-dependently increases urinary glucose excretion, with effects lasting over 12 hours in normal mice at doses of 0.3 mg/kg or higher.
- Single administration dose-dependently increases urinary glucose excretion, reduces blood glucose and plasma insulin levels, and improves glucose intolerance.
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