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Medchemexpress LLC Iptacopan (hydrochloride) | 1646321-63-2 | 99.83% | 25 MG
Supplier: Medchemexpress LLC 25MGHY127105A
Iptacopan (LNP023) hydrochloride is an effective, orally-active, and highly selective factor B inhibitor. With an IC50 of 10 nM and a KD of 7.9 nM, it exerts a proximal effect in the complement cascade reaction, preventing the destruction of red blood cells in PNH and damage to renal cells in IgAN and C3G. It is used for studying complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G).
- Highly selective factor B inhibitor.
- Orally active.
- Potent inhibition of alternative complement pathway (AP)-induced membrane attack complex (MAC) formation.
- Excellent selectivity over other proteases.
- Prevents destruction of red blood cells in PNH.
- Prevents damage to renal cells in IgAN and C3G.
- Used for studying complement-mediated diseases.
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