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Medchemexpress LLC Iptacopan (hydrochloride) | 1646321-63-2 | 99.83% | 458.98 | 5 MG
Supplier: Medchemexpress LLC 5MGHY127105A
Iptacopan hydrochloride is an effective, orally-active, and highly selective factor B inhibitor. It acts proximally in the complement cascade, preventing red blood cell destruction in paroxysmal nocturnal hemoglobinuria (PNH) and renal cell damage in immunoglobulin A nephropathy (IgAN) and complement 3 glomerulopathy (C3G).
- Effective, orally-active, and highly selective factor B inhibitor
- IC50 value of 10 nM and KD of 7.9 nM for factor B
- Prevents red blood cell destruction in PNH
- Prevents renal cell damage in IgAN and C3G
- Inhibits alternative complement pathway (AP)-induced membrane attack complex (MAC) formation
- Exhibits excellent selectivity over other proteases
- Used for studying complement-mediated diseases
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