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Cayman Chemical IRAK4 InhIbItr 28 25mg
Supplier: Cayman Chemical 4016725 MG
An IRAK4 inhibitor (IC50 = 0.005 µM); selective for IRAK4 over IRAK1, Clk1, and Clk3 (IC50s = 0.023, 0.05, and >1 µM, respectively) but does inhibit Clk2, Clk4, and haspin (IC50s = 0.005, 0.008, and 0.004 µM, respectively); inhibits IκBα phosphorylation in OCI-LY10 DLBCL cells from 0.12-3.3 µM; reduces tumor volume in an OCI-LY10 mouse xenograft model at 12.5 mg/kg
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