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Apexbio Technology LLC Irsogladine 57381-26-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B15935.1
Irsogladine (CAS 57381-26-7) is a small molecule inhibitor of phosphodiesterase 4 (PDE4) and exhibits binding affinity for muscarinic acetylcholine receptors In preclinical studies irsogladine administration at 300 and 500 mg/kg/day produced a dose-dependent suppression of angiogenesis in wild-type mice reducing neovascularization by 21% and 45 3% respectively with statistical significance (P 0 02 P 0 001) These properties support its utility in investigating the modulation of cyclic AMP signaling cholinergic pathways and angiogenesis in biomedical research contexts
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