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Apexbio Technology LLC Isatin 91-56-5 500mg
Supplier: Apexbio Technology LLC B6153500
Isatin (CAS 91-56-5) is a small molecule inhibitor of monoamine oxidase (MAO) exhibiting an IC50 of 15 M Monoamine oxidase inhibitors are investigated for their roles in modulating neurotransmitter metabolism and have been explored in the management of depressive disorders and neurodegenerative diseases such as Parkinson s disease In vitro exposure of SH-SY5Y neuroblastoma cells to isatin induces a dose-dependent increase in MTT metabolism and at higher concentrations promotes cell death characterized by a shift from apoptosis at lower doses to increased necrosis at higher doses In vivo isatin treatment in a rat model of Japanese encephalitis virus-induced Parkinsonism enhances motor activity and prevents dopamine depletion in the striatum indicating its utility in neuropharmacological research
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