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STEMCELL Technologies ISCK03, Size: 10 mg
Supplier: STEMCELL Technologies 73734
ISCK03 (inhibitor of SCF/c-KIT) is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits KIT activity. ISCK03 inhibits SCF-induced c-KIT phosphorylation and downstream ERK phosphorylation at a concentration of 1 - 5 µM in 501mel melanoma cells (Na et al.).CANCER RESEARCH· Causes significant decrease in blood vessel density on human lung adenocarcinoma (A549) cells irradiated with X-rays (6 Gy; Kamlah et al.).· Reduces cell viability and ERK1/2 phosphorylation in acute myeloid leukemia (AML)-derived cell lines (Kon et al.).
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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