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Cayman Chemical IsopImarIc AcId 5mg
Supplier: Cayman Chemical 345445 MG
A diterpenoid resin acid; active against clinical isolates of EMRSA (MICs = 32-64 UG/ml); an agonist of RXRα, RXRβ, and RXRγ in a reporter assay using HEK293T cells expressing human receptors (EC50s = 26, 32, and 33 µM, respectively); opens BKCa1.1/KCa1.1 in HEK293 cells expressing recombinant channels and the activating β1 regulatory subunit at 10 µM; potentiates reductions in fEPSP slopes in hippocampal slices and decreases escape latency in the Morris water maze in a 3xTg mouse model of Alzheimer's disease; has been found in pulp and paper mill effluent
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