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Medchemexpress LLC Isradipine | 75695-93-1 | 99.9% | 50 MG
SDP

Supplier:  Medchemexpress LLC HYB023350MG

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Isradipine is an orally active, blood-brain barrier permeable L-type calcium channel blocker. It acts as a potent peripheral vasodilator and is a dihydropyridine calcium antagonist with selective effects on both the heart and peripheral circulation. It is also considered a potentially viable neuroprotective agent for Parkinson's disease.

  • Targets L-type calcium channels.
  • Inhibits L-type calcium channel in HEK293 cells with an IC50 of 0.0022 μM.
  • Antagonist for Cav1.2alpha-1C and Cav1.3alpha-1D channels.
  • Shows significantly higher affinity for Cav1.3 channels and good brain bioavailability.
  • Increases sodium excretion in rats.
  • Reduces 6-hydroxydopamine induced neurotoxicity at the striatal level.
  • Protects striatal dopaminergic terminals and SNc dopaminergic cell bodies.

Catalog No. 50-004-05694


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