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Apexbio Technology LLC IT1t dihydrochloride 1092776-63-0 50mg
Supplier: Apexbio Technology LLC B565050
IT1t dihydrochloride (CAS 1092776-63-0) is a small-molecule antagonist targeting the chemokine receptor CXCR4 It is designed to inhibit CXCR4-mediated signaling by disrupting interactions with its natural ligand CXCL12 as well as the HIV envelope protein gp120 thereby interfering with cellular chemotaxis and viral entry mechanisms IT1t dihydrochloride exerts its biological activity primarily by antagonizing CXCR4 to inhibit receptor-mediated Ca2 mobilization and virus attachment In in vitro assays IT1t dihydrochloride demonstrates potent inhibition with IC50 values of approximately 8 nM in human CXCR4 receptor binding assays 1 1 nM in Ca2 mobilization assays and 7 nM in HIV attachment assays Based on these pharmacological properties IT1t dihydrochloride holds research potential in CXCR4-related signaling and HIV entry studies
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