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Cayman Chemical IT1thydrochlorIde 10mg
Supplier: Cayman Chemical 2843410 MG
A CXCR4 antagonist (IC50s = 8 and 11 nM for the human and rat receptors, respectively); selective for CXCR4 over hERG/Kv11.1 (IC50 = 13,240 nM); inhibits CXCL12-induced calcium mobilization in CEM cells (IC50 = 1.1 nM) and decreases CXCL12-induced migration of Jurkat cells (IC50 = 79.1 nM); inhibits replication of the HIV-1 strain NL4-3 in MT-4 cells and isolated PHA-stimulated PBMCs; reduces tumor growth in an MDA-MB-231-B zebrafish xenograft model at 20 µM
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