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AdipoGen Itaconic acid 4-octyl ester
SDP

Supplier:  AdipoGen AGCR13700M010

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Chemical. CAS 3133-16-2. Formula C13H22O4. MW 242.3. Derivative of itaconate AG-CN2-0426 https//adipogen.com/ag-cn2-0426-itaconic-acid.html with enhanced cell permeability. Prodrug that is efficiently metabolized to itaconate in cells. Potent anti-inflammatory agent. In vitro it activates the transcription factor nuclear factor erythroid 2-related factor 2 Nrf2 also known as NFE2L2 in LPS-induced mouse and human macrophages. Upregulates Nrf2 levels via a newly identified post-translational modification, dicarboxylation of KEAP1. Alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream gene. Cysteine 151 is uniquely required for inhibiting KEAP1-mediated degradation of Nrf2 and mutating this residue in KEAP1 prevents the stabilization of Nrf2.

Catalog No. 50-256-2203


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