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Cayman Chemical Itraconazole 100mg
SDP

Supplier:  Cayman Chemical 13288100 MG

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An antifungal agent and hedgehog pathway inhibitor; inhibits hedgehog signaling (IC50 = 0.8 μM); binds to 14-α sterol demethylase/CYP51 isoform B (Kd = 31 nM for A. fumigatus enzyme expressed in E. coli); inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after 16 hours); inhibits C. neoformans growth by 50% at 3.2 nM; suppresses growth of medulloblastomas in a Ptch+/-p53-/- mouse allograft model at 100 mg/kg twice daily; reduces viral titers of several enteroviruses in infected cells from 1.25-100 µM

Catalog No. 50-295-3678


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