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Apexbio Technology LLC ITSA-1 (ITSA1) 200626-61-5 100mg
Supplier: Apexbio Technology LLC B7816100
ITSA-1 (CAS 200626-61-5) is a small molecule identified as an activator of histone deacetylases (HDACs) specifically modulating the HDAC activity suppressed by trichostatin A (TSA) While TSA is a potent inhibitor of mammalian HDACs that induces accumulation of acetylated histones ITSA-1 counteracts TSA-induced histone acetylation In vitro studies demonstrate that ITSA-1 restores BrdU incorporation and normal cell cycle distribution in TSA-treated mouse embryonic stem cells and reduces acetylated histone H3 levels in TSA-exposed A549 cells ITSA-1 alone does not affect HDAC activity indicating an indirect modulatory mechanism ITSA-1 is primarily used as a probe to study intracellular histone acetylation and regulatory pathways of HDAC function
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