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Medchemexpress LLC Iturin A | 52229-90-0 | 98.5% | 1043.2 | 1 MG
Supplier: Medchemexpress LLC HYP23221MG
Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A also demonstrates antitumor activity.
- Inhibits *Fusarium graminearum* conidial activity and germination at low concentrations in vitro.
- Inhibits cell growth, induces cell cycle arrest, ROS outburst, apoptosis, and autophagy in HepG2 cells in vitro.
- Shows antitumor activity in a mouse model of liver cancer, significantly inhibiting tumor growth and inducing apoptosis and autophagy of tumor cells.
- Improved the tumor immune microenvironment in mice.
- Had no significant influence on body weight, food intake, and viscera index in mice.
- Interfered with the liver function of mice, but had no significant effect on renal function and was safe to the kidney and spleen.
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