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Medchemexpress LLC Izuforant (JW1601) | 1429374-83-3 | 98.9% | 334.17 | 5 MG
Supplier: Medchemexpress LLC HY1472765MG
Izuforant (JW1601) is an orally active histamine H4 receptor (H4R) antagonist with an IC50 of 36 nM against human H4R. It also shows binding affinity to the human serotonin 3 receptor (h5-HT3R) with an IC50 of 9.1 μM. This compound exhibits strong anti-pruritic and anti-inflammatory efficacies and is suitable for research applications.
- Orally active histamine H4 receptor antagonist
- Binds to human serotonin 3 receptor
- Exhibits strong anti-pruritic and anti-inflammatory efficacies
- Shows metabolic stability in mouse and human
- Decreases histamine- and substance P-induced itching
- Inhibits oxazolone-induced atopic dermatitis
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