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Medchemexpress LLC Jak-in-1 | 1334673-53-8 | 98.4% | 380.44 | 100 MG
Supplier: Medchemexpress LLC HY13827100MG
JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8, and 3.2 nM, respectively. It exhibits improved selectivity for JAK3 over JAK1. This compound inhibits the proliferation of human CD4 and CD8 T cells in a dose-dependent manner upon stimulation and is active in both mechanistic and functional cell-based assays using T-cells. In vivo, it is JAK3 selective, potently inhibits IL-2 stimulated plasma concentrations, and prevents IL-2-driven STAT5 phosphorylation.
- Inhibits proliferation of human CD4 and CD8 T cells in a dose-dependent manner.
- Active in both mechanistic and functional cell-based assays using T-cells.
- Exhibits JAK3 selectivity in vivo.
- Potently inhibits IL-2 stimulated plasma concentrations.
- Prevents IL-2-driven STAT5 phosphorylation in a dose- and concentration-dependent manner.
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